Chiral drug metabolism: a perspective.

456 biggest problems is in understanding the fundamental mechanisms involved and predicting the CSP to be used for specific problems. Although Pirkle phases and cyclodextrin phases offer the best rationale for use, in general most decisions are based on empirical experiments, with a degree of justification post fact0 in terms of the proposed mechanism involved. The protein columns based on AGP and ovomucoid have shown the widest range of applicability so far, although the mechanisms of chiral recognition on these phases are by no means fully understood.